The singer will take to the stage at the city's Ryman Auditorium on March 20th, in aid of the charity's Blue Note Fund as part of America's National Colorectal Cancer Awareness month.
Jackson became involved with the charity when his wife, Denise, developed the disease in 2010.
He says, "It knocked us both down. It was so hard to watch her go through that... I felt like there wasn't a thing I could do."
Denise adds, "That really brought to my attention the CCA and what the organization does, and more specifically what the Blue Note Fund does for the Nashville area and the rest of the country as well."
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